Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome

@article{Yoshimoto2008AbsenceOT,
  title={Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome},
  author={Maisa Yoshimoto and Anthony Michael Joshua and Isabela Werneck da Cunha and Renata de Almeida Coudry and Francisco Paulo da Fonseca and Olga Ludkovski and Maria Zielenska and Fernando Augusto Soares and Jeremy A Squire},
  journal={Modern Pathology},
  year={2008},
  volume={21},
  pages={1451-1460}
}
TMPRSS2:ERG gene fusions and PTEN deletions are the most common genomic aberrations in prostate cancer. Recent work has suggested that the TMPRSS2:ERG fusion is associated with a more aggressive phenotype. Similarly, PTEN deletion has been associated with biochemical recurrence and lymph node metastasis. To date, there has been no systematic analysis of the combined influence of genomic PTEN deletion with TMPRSS2:ERG gene fusions on clinical parameters of prostate cancer progression. We carried… CONTINUE READING
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97th Annual Meeting of the United States and Canadian Academy of Pathology

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