Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy.

Abstract

Oxidative stress is commonly implicated in the pathogenesis of motor neuron disease. However, the cause and effect relationship between oxidative stress and motor neuron degeneration is poorly defined. We recently identified denervation at the neuromuscular junction in mice lacking the antioxidant enzyme, Cu,Zn-superoxide dismutase (SOD1) (Fischer et al… (More)
DOI: 10.1016/j.expneurol.2011.09.020

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Cite this paper

@article{Fischer2012AbsenceOS, title={Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy.}, author={Lindsey R. Fischer and Yingjie Li and Seneshaw A Asress and Dean P. Jones and Jonathan D. Glass}, journal={Experimental neurology}, year={2012}, volume={233 1}, pages={163-71} }