Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.

@article{Bartsch2017AbsenceOR,
  title={Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.},
  author={Kareen Bartsch and Katharina Knittler and Christopher Borowski and S{\"o}nke Rudnik and Markus Damme and Konrad Aden and Martina Elisabeth Spehlmann and Norbert Frey and Paul Saftig and Athena Chalaris and B. Khadem Rabe},
  journal={Human molecular genetics},
  year={2017},
  volume={26 20},
  pages={3960-3972}
}
Hypomorphic mutations in the DNA repair enzyme RNase H2 cause the neuroinflammatory autoimmune disorder Aicardi-Goutières syndrome (AGS). Endogenous nucleic acids are believed to accumulate in patient cells and instigate pathogenic type I interferon expression. However, the underlying nucleic acid species amassing in the absence of RNase H2 has not been established yet. Here, we report that murine RNase H2 knockout cells accumulated cytosolic DNA aggregates virtually indistinguishable from… CONTINUE READING

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