Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice.

@article{Ren2003AbsenceON,
  title={Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice.},
  author={Jun Ren and Syann Lee and Silvia Pagliardini and Matthieu G{\'e}rard and Colin Lawson Stewart and John J. Greer and Rachel Wevrick},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 5},
  pages={1569-73}
}
necdin (Ndn) is one of a cluster of genes deleted in the neurodevelopmental disorder Prader-Willi syndrome. necdin is upregulated during neuronal differentiation and is thought to play a role in cell cycle arrest in terminally differentiated neurons. Most necdin-deficient Ndn(tm2Stw) mutant pups carrying a targeted replacement of Ndn with a lacZ reporter gene die in the neonatal period of apparent respiratory insufficiency. We now demonstrate that the defect can be explained by abnormal… CONTINUE READING
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PreBötzinger complex: a brainstem region that may generate respiratory rhythm in mammals

  • JC Smith, HH Ellengerger, K Ballanyi, DW Richter, JL Feldman
  • Science
  • 1991
Highly Influential
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