Absence of Epstein-Barr virus DNA in the tumor cells of European hepatocellular carcinoma.

@article{Junying2003AbsenceOE,
  title={Absence of Epstein-Barr virus DNA in the tumor cells of European hepatocellular carcinoma.},
  author={Jia Junying and Kathrin Herrmann and Gillian T. Davies and David Lissauer and Andrew I Bell and Judith Timms and Gary M. Reynolds and Stefan G. Hubscher and Lawrence S Young and Gerald U. Niedobitek and Paul Gerard Murray},
  journal={Virology},
  year={2003},
  volume={306 2},
  pages={
          236-43
        }
}
The Epstein-Barr virus (EBV) has recently been associated with hepatocellular carcinoma (HCC) arising in Japanese patients. We analyzed 82 cases of HCC from Germany and the U.K. for the presence of EBV DNA and viral gene products within tumor cells. Initial screening of whole sections using quantitative (Q)-PCR detected EBV DNA in 9/58 U.K. cases and in 9/24 German cases; in positive cases viral load was very low, ranging between 1.4 and 49.1 copies of the EBV genome/1000 cell equivalents… CONTINUE READING
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