Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice

@article{Johansen1999AbsenceOE,
  title={Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice},
  author={Finn-Eirik Johansen and Marcela Pekna and Inger Natvig Norderhaug and Bj\orn Haneberg and Max Albert Hietala and Peter Krajci and Christer Betsholtz and P E R Brandtzaeg},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={190},
  pages={915 - 922}
}
Mucosal surfaces are protected specifically by secretory immunoglobulin A (SIgA) and SIgM generated through external translocation of locally produced dimeric IgA and pentameric IgM. Their active transport is mediated by the epithelial polymeric Ig receptor (pIgR), also called the transmembrane secretory component. Paracellular passive external transfer of… CONTINUE READING