Absence of DNA damage in liver of rats given high doses of cimetidine and sodium nitrite.

@article{Brambilla1982AbsenceOD,
  title={Absence of DNA damage in liver of rats given high doses of cimetidine and sodium nitrite.},
  author={Giovanni Brambilla and Marco Cavanna and A L Maura and Albiana Pino and Luigi Robbiano and Pia Carlo and F Biassoni and Roberta Ricci},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={221 1},
  pages={222-7}
}
A correlation between cimetidine and gastric cancer has been suggested. Nitrosation of cimetidine in the presence of nitrite and HCl and mutagenic activity as well as DNA damage in mammalian cells displayed by nitrosocimetidine, as these phenomena occur in vitro, were the supporting hypothesis. Previous studies have shown that liver DNA damage was a well… CONTINUE READING