Absence of DAB2IP promotes cancer stem cell like signatures and indicates poor survival outcome in colorectal cancer

@inproceedings{Min2015AbsenceOD,
  title={Absence of DAB2IP promotes cancer stem cell like signatures and indicates poor survival outcome in colorectal cancer},
  author={Jiang Min and Liang Liu and Xiaolan Li and Jianwu Jiang and Jingtao Wang and Bo Zhang and Dengyi Cao and Dongdong Yu and Deding Tao and Junbo Hu and Jian-ping Gong and D Xie},
  booktitle={Scientific reports},
  year={2015}
}
Metastasis is a critical factor for the high mortality of colorectal cancer (CRC), but its mechanism is not completely understood. Epithelial-mesenchymal transition (EMT) is thought to play a key role in metastasis and also increases the cancer stem cell (CSC) feature that facilitates metastatic colonization. In this study, we investigated the biological roles of DAB2IP regulating EMT and stem cell-like features in human CRC. We demonstrate that DAB2IP suppresses NF-κB-mediated EMT and CSC… CONTINUE READING