Absence of Correlation Between BMP-4 Polymorphism and Postmenopausal Osteoporosis in Italian Women

@article{Semprini2000AbsenceOC,
  title={Absence of Correlation Between BMP-4 Polymorphism and Postmenopausal Osteoporosis in Italian Women},
  author={Sabrina Semprini and Ruggiero Mango and Francesco Brancati and Bruno Dallapiccola and Lucia Becherini and Giuseppe Novelli and Antonino De Lorenzo and Maria Luisa Brandi and L Gennari},
  journal={Calcified Tissue International},
  year={2000},
  volume={67},
  pages={93-94}
}
Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We investigated the association of BMP-4 gene polymorphism with osteoporosis in a cohort of 72 osteoporotic, postmenopausal women and 82 unrelated controls. We failed to detect any… CONTINUE READING
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