Absence of Caspase 8 and High Expression of PED Protect Primitive Neural Cells from Cell Death

@article{RicciVitiani2004AbsenceOC,
  title={Absence of Caspase 8 and High Expression of PED Protect Primitive Neural Cells from Cell Death},
  author={Lucia Ricci-Vitiani and Francesca Pedini and Cristiana Mollinari and Gerolama Condorelli and Daniela Maria Oliveira Bonci and Alessandra da Silveira Bez and Augusto Colombo and Eugenio Parati and Cesare Peschle and Ruggero de Maria},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={200},
  pages={1257 - 1266}
}
The mechanisms that control neural stem and progenitor cell survival are unknown. In several pathological conditions, death receptor (DR) ligands and inflammatory cytokines exert a deleterious effect on neurons, whereas primitive neural cells migrate and survive in the site of lesion. Here, we show that even in the presence of inflammatory cytokines, DRs are unable to generate death signals in primitive neural cells. Neural stem and progenitor cells did not express caspase 8, the presence of… CONTINUE READING

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