Absence of Caspase 8 and High Expression of PED Protect Primitive Neural Cells from Cell Death

  title={Absence of Caspase 8 and High Expression of PED Protect Primitive Neural Cells from Cell Death},
  author={L. Ricci‐Vitiani and F. Pedini and C. Mollinari and G. Condorelli and D. Bonci and A. Bez and Augusto Colombo and E. Parati and C. Peschle and R. de Maria},
  journal={The Journal of Experimental Medicine},
  pages={1257 - 1266}
  • L. Ricci‐Vitiani, F. Pedini, +7 authors R. de Maria
  • Published 2004
  • Biology, Medicine
  • The Journal of Experimental Medicine
  • The mechanisms that control neural stem and progenitor cell survival are unknown. In several pathological conditions, death receptor (DR) ligands and inflammatory cytokines exert a deleterious effect on neurons, whereas primitive neural cells migrate and survive in the site of lesion. Here, we show that even in the presence of inflammatory cytokines, DRs are unable to generate death signals in primitive neural cells. Neural stem and progenitor cells did not express caspase 8, the presence of… CONTINUE READING
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