Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits

@article{Peagarikano2011AbsenceOC,
  title={Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits},
  author={Olga Pe{\~n}agarikano and Brett S. Abrahams and Edward I. Herman and Kellen Diamond Winden and Amos Gdalyahu and Hongmei Dong and Lisa I. Sonnenblick and Robin Gruver and Joel Almajano and Anatol Bragin and Peyman Golshani and Joshua T. Trachtenberg and Elior Peles and Daniel H. Geschwind},
  journal={Cell},
  year={2011},
  volume={147},
  pages={235-246}
}
Although many genes predisposing to autism spectrum disorders (ASD) have been identified, the biological mechanism(s) remain unclear. Mouse models based on human disease-causing mutations provide the potential for understanding gene function and novel treatment development. Here, we characterize a mouse knockout of the Cntnap2 gene, which is strongly associated with ASD and allied neurodevelopmental disorders. Cntnap2(-/-) mice show deficits in the three core ASD behavioral domains, as well as… CONTINUE READING
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