Absence of CHEK2*1100delC mutation in families with hereditary breast cancer in North America.

@article{Iniesta2010AbsenceOC,
  title={Absence of CHEK2*1100delC mutation in families with hereditary breast cancer in North America.},
  author={Mar{\'i}a Dolores Iniesta and Michael A Gorin and Ling-Chen Chien and Samantha Thomas and Kara J Milliron and Julie A. Douglas and Sof{\'i}a D. Merajver},
  journal={Cancer genetics and cytogenetics},
  year={2010},
  volume={202 2},
  pages={136-40}
}
The CHEK2*1100delC mutation has been reported to confer a twofold increased risk of breast cancer among carriers. The frequency of the mutation varies among populations. The highest frequency has been described in Northern and Eastern European countries; the frequency may be much lower in North America. In this study, our aim was to determine the frequency… CONTINUE READING