Absence of  “Original Antigenic Sin” in Autoimmunity Provides an Unforeseen Platform for Immune Therapy


I n this issue of The Journal of Experimental Medicine , Tuohy et al. study the spreading of the autoimmune response to myelin antigens in experimental autoimmune encephalo-myelitis (EAE) and its likely human counterpart, multiple sclerosis (MS) (1). They demonstrate that as disease develops in EAE and MS, reactivity to the initiating antigen diminishes… (More)


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