Abscopal effect of low-LET γ-radiation mediated through Rel protein signal transduction in a mouse model of nontargeted radiation response

@article{Aravindan2014AbscopalEO,
  title={Abscopal effect of low-LET $\gamma$-radiation mediated through Rel protein signal transduction in a mouse model of nontargeted radiation response},
  author={S. Aravindan and M. Natarajan and S. Ramraj and V. Pandian and F. H. Khan and T. Herman and N. Aravindan},
  journal={Cancer Gene Therapy},
  year={2014},
  volume={21},
  pages={54-59}
}
Ascertaining the ionizing radiation (IR)-induced bystander response and its preceding molecular regulation would increase our understanding of the mechanism of acute and delayed radiobiological effects. [...] Key Method Heart tissues from C57/BL6 mice either mock irradiated or exposed (limited to lower abdomen 1 cm diameter) to single-dose IR (SDR: 2 or 10 Gy) or fractionated IR (FIR, 2 Gy per day for 5 days) were examined for onset of abscopal NF-κB signal transduction, translated activity, downstream…Expand
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