Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro.

@article{Bruzzone2012AbscisicAA,
  title={Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro.},
  author={Santina Bruzzone and Florinda Battaglia and Elena Mannino and Alessia Parodi and Floriana Fruscione and Giovanna Basile and Annalisa Salis and Laura Sturla and Simone Maria Negrini and Francesca Kalli and Silvia Stringara and Gilberto Filaci and Elena Zocchi and Daniela Fenoglio},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={422 1},
  pages={70-4}
}
The phytohormone abscisic acid (ABA) has been recently identified as an endogenous hormone in humans, regulating different cell functions, including inflammatory processes, insulin release and glucose uptake. Systemic sclerosis (SSc) is a chronic inflammatory disease resulting in fibrosis of skin and internal organs. In this study, we investigated the effect of exogenous ABA on fibroblasts obtained from healthy subjects and from SSc patients. Migration of control fibroblasts induced by ABA was… CONTINUE READING