Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s).

@article{Redwood1992AbrogationOT,
  title={Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s).},
  author={Sheila Redwood and Brian C.-S. Liu and Robert E. Weiss and D E Hodge and Michael J. Droller},
  journal={Cancer},
  year={1992},
  volume={69 5},
  pages={
          1212-9
        }
}
It was shown previously that invasive human transitional cell carcinoma cell line EJ, but not the noninvasive RT4 cells, can degrade basement membrane laminin and that the degradation of basement membrane laminin was a result of a redistribution of activated cysteine proteinase cathepsin B to the plasma membrane of the invasive EJ cells. Using a modified Boyden chamber and an artificial basement membrane, it was found first that cysteine proteinase inhibitor E-64 can abolish the ability of the… CONTINUE READING

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Down-regulation of S100C is associated with bladder cancer progression and poor survival.

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