Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells.

@article{Russell1995AbrogationOT,
  title={Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells.},
  author={Kenneth J. Russell and Linda W. Wiens and Gwendeline Demers and Denise A. Galloway and Sharon E. Plon and Mark Groudine},
  journal={Cancer research},
  year={1995},
  volume={55 8},
  pages={1639-42}
}
We have examined the effect of abrogation of the G2 checkpoint on the radiosensitivity of G1 checkpoint-proficient and G1 checkpoint-deficient cells. A549 human lung adenocarcinoma cells were transduced with the E6 oncogene of the human papillomavirus type 16 to eliminate their radiation-induced G1 arrest. These E6+ cells exhibited a dose-dependent increase in radiation resistance compared to control A549 cells transduced with the vector alone. Treatment (96 h) with 2 mM caffeine resulted in an… CONTINUE READING
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