Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

@article{Lowe1994AbrogationOO,
  title={Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.},
  author={Scott W Lowe and Tyler 8 Jacks and David Housman and H. Earl Ruley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 6},
  pages={2026-30}
}
p53-deficient mouse embryonic fibroblasts were used to establish a direct mechanism of tumor suppression by p53 involving the destruction of oncogene-expressing cells by apoptosis. The absence of p53 enhanced cell growth, appeared sufficient for immortalization, and allowed a single oncogene [adenovirus early region 1A (E1A)] to transform cells to a tumorigenic state. p53 suppressed transformation of E1A-expressing cells by apoptosis. Apoptosis was associated with p53 stabilization and was… CONTINUE READING
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