Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.

@article{Wang2009AbrogationOH,
  title={Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.},
  author={Qiong Wang and Lei Jiang and Jue Wang and Shoufeng Li and Yue Yu and Jia You and Rong Zeng and Xiang Gao and Liangyou Rui and Wenjun Li and Yong Liu},
  journal={Hepatology},
  year={2009},
  volume={49 4},
  pages={1166-75}
}
UNLABELLED Hepatic steatosis is a hallmark of nonalcoholic fatty liver disease (NAFLD) and a key component of obesity-associated metabolic dysfunctions featuring dyslipidemia, insulin resistance, and loss of glycemic control. It has yet to be completely understood how much dysregulated de novo lipogenesis contributes to the pathogenic development of hepatic steatosis and insulin resistance. ATP-citrate lyase (ACL) is a lipogenic enzyme that catalyzes the critical reaction linking cellular… CONTINUE READING
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