Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency.


BACKGROUND Major features of allergic asthma include airway hyperresponsiveness (AHR), eosinophilic inflammation, and goblet cell metaplasia. Rho kinase (ROCK) is a serine/threonine protein kinase that regulates the actin cytoskeleton. By doing so, it can modulate airway smooth muscle cell contraction and leucocyte migration and proliferation. This study… (More)
DOI: 10.1111/cea.12438