Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.

@article{Yang2008AbrogationOT,
  title={Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.},
  author={Li Yang and Jianhua Huang and Xiubao Ren and Agnieszka E. Gorska and Anna M Chytil and Mary E. Aakre and David Paul Carbone and Lynn M Matrisian and Ann Richmond and Pengnian Charles Lin and Harold L. Moses},
  journal={Cancer cell},
  year={2008},
  volume={13 1},
  pages={23-35}
}
Aberrant TGFbeta signaling is common in human cancers and contributes to tumor metastasis. Here, we demonstrate that Gr-1+CD11b+ myeloid cells are recruited into mammary carcinomas with type II TGF beta receptor gene (Tgfbr2) deletion and directly promote tumor metastasis. Gr-1+CD11b+ cells infiltrate into the invasive front of tumor tissues and facilitate tumor cell invasion and metastasis through a process involving metalloproteinase activity. This infiltration of Gr-1+CD11b+ cells also… CONTINUE READING
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