Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event.

@article{Corvol2008AbrogationOT,
  title={Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event.},
  author={Jean-Christophe Corvol and Daniel Pelletier and Roland G. Henry and Stacy J. Caillier and Joanne H. Wang and Derek Pappas and Simona Casazza and Darin Okuda and Stephen L. Hauser and Jorge Oksenberg and Sergio E Baranzini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 33},
  pages={11839-44}
}
Clinically isolated syndrome (CIS) refers to the earliest clinical manifestation of multiple sclerosis (MS). Currently there are no prognostic biological markers that accurately predict conversion of CIS to clinically definite MS (CDMS). Furthermore, the earliest molecular events in MS are still unknown. We used microarrays to study gene expression in naïve CD4(+) T cells from 37 CIS patients at time of diagnosis and after 1 year. Supervised machine-learning methods were used to build… CONTINUE READING