Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition.

@article{Willemsen2005AbrogationOI,
  title={Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition.},
  author={Linette E. M. Willemsen and J P Hoetjes and Sander J. van Deventer and Eric A. F. van Tol},
  journal={Clinical and experimental immunology},
  year={2005},
  volume={142 2},
  pages={275-84}
}
The intestinal barrier function is often impaired in a variety of diseases including chronic inflammatory bowel disease. Increased intestinal permeability during episodes of active disease correlates with destruction or rearrangement of the tight junction protein complex. IFN-gamma has been widely studied for its effect on barrier function and tight junction structures but its mode of action remains unclear. Since the claudin family of tight junction proteins is proposed to be involved in… CONTINUE READING
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