Abrogation of Brd4 cellular function contributes to the oncogenic mechanisms of translocation t(15;19)-associated carcinoma

@inproceedings{Wang2013AbrogationOB,
  title={Abrogation of Brd4 cellular function contributes to the oncogenic mechanisms of translocation t(15;19)-associated carcinoma},
  author={Ranran Wang and Christine M Heifer and Jianxin You},
  booktitle={Epigenetics & Chromatin},
  year={2013}
}
Background Brd4 (bromodomain-containing protein 4) is an important epigenetic reader that plays a crucial role in cellular proliferation and cell cycle progression. Several recent studies have identified Brd4 as a critical therapeutic target in a number of different cancers. Brd4 is also an important target of several oncogenic viruses and the translocation t (15;19) that accounts for a highly aggressive carcinoma. The t(15;19) translocation results in the novel in-frame fusion of the Brd4 N… CONTINUE READING