Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.

@article{Vredeveld2012AbrogationOB,
  title={Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.},
  author={Liesbeth C. W. Vredeveld and Patricia Abr{\~a}o Possik and Marjon A. Smit and Katrin Meissl and Chrysiis Michaloglou and Hugo M. Horlings and Abderrahim Ajouaou and Pim C Kortman and David Dankort and Martin McMahon and Wolter J. Mooi and Daniel S Peeper},
  journal={Genes & development},
  year={2012},
  volume={26 10},
  pages={1055-69}
}
Human melanocytic nevi (moles) are benign lesions harboring activated oncogenes, including BRAF. Although this oncogene initially acts mitogenically, eventually, oncogene-induced senescence (OIS) ensues. Nevi can infrequently progress to melanomas, but the mechanistic relationship with OIS is unclear. We show here that PTEN depletion abrogates BRAF(V600E… CONTINUE READING
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