AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels.


AbrB is a key transition-state regulator of Bacillus subtilis. Based on the conservation of a betaalphabeta structural unit, we proposed a beta barrel fold for its DNA binding domain, similar to, but topologically distinct from, double-psi beta barrels. However, the NMR structure revealed a novel fold, the "looped-hinge helix." To understand this… (More)


6 Figures and Tables