• Corpus ID: 15862758

Abortive Initiation as a Bottleneck for Transcription in the Early Drosophila Embryo

@article{Serov2017AbortiveIA,
  title={Abortive Initiation as a Bottleneck for Transcription in the Early Drosophila Embryo},
  author={Alexander S. Serov and A J Levine and Madhav Mani},
  journal={arXiv: Biological Physics},
  year={2017}
}
Gene transcription is a critical step in gene expression. The currently accepted physical model of transcription predicts the existence of a physical limit on the maximal rate of transcription, which does not depend on the transcribed gene. This limit appears as a result of polymerase "traffic jams" forming in the bulk of the 1D DNA chain at high polymerase concentrations. Recent experiments have, for the first time, allowed one to access live gene expression dynamics in the Drosophila fly… 

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