Abortion in mice with excessive erythrocytosis is due to impaired arteriogenesis of the uterine arcade.

@article{Gassmann2008AbortionIM,
  title={Abortion in mice with excessive erythrocytosis is due to impaired arteriogenesis of the uterine arcade.},
  author={Max Gassmann and Annamaria Manini and Thomas Stallmach and Bianca Saam and Gisela Kuhn and Beat Grenacher and Anna Yu. Bogdanova and Johannes Vogel},
  journal={Biology of reproduction},
  year={2008},
  volume={78 6},
  pages={1049-57}
}
We postulate that repeated pregnancy loss, intrauterine growth restriction, and preeclampsia are caused by impaired elevation of uterine blood flow due to disturbed arteriogenesis of the uterine arcade. This hypothesis is based on the observation that pregnant human erythropoietin-overexpressing (plasma levels elevated 12-fold) mice (termed tg6 mice) suffering from excessive erythrocytosis generally abort at midgestation unless their hematocrit of 0.85 is drastically lowered. Transgenic mice… CONTINUE READING

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