Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide.

@article{Heiser2011AbortedGC,
  title={Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide.},
  author={Ryan A. Heiser and Christopher M Snyder and James St Clair and Lawrence J Wysocki},
  journal={Journal of immunology},
  year={2011},
  volume={187 1},
  pages={
          212-21
        }
}
A fundamental problem in immunoregulation is how CD4(+) T cells react to immunogenic peptides derived from the V region of the BCR that are created by somatic mechanisms, presented in MHC II, and amplified to abundance by B cell clonal expansion during immunity. BCR neo Ags open a potentially dangerous avenue of T cell help in violation of the principle of… CONTINUE READING