Abolition of morphine-immunosuppression in mice lacking the mu-opioid receptor gene.

  title={Abolition of morphine-immunosuppression in mice lacking the mu-opioid receptor gene.},
  author={Claire Gav{\'e}riaux-Ruff and H. W. Matthes and Jean Peluso and Brigitte Lina Kieffer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 11},
Opiates are potent analgesic and addictive compounds. They also act on immune responses, and morphine, the prototypic opiate, has been repeatedly described as an immunosuppressive drug. Pharmacological studies have suggested that the inhibitory action of opiates on immunity is mediated by multiple opioid receptor sites but molecular evidence has remained elusive. Recently, three genes encoding mu- (MOR), delta-, and kappa-opioid receptors have been cloned. To investigate whether the mu-opioid… CONTINUE READING
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