Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice.

@article{Brown2001AbolishedTF,
  title={Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice.},
  author={Russell D. Brown and Anna Ollerstam and B Johansson and Ole Sk\ott and Samuel Gebre-Medhin and Bertil B. Fredholm and Anders Erik Gosta Persson},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2001},
  volume={281 5},
  pages={R1362-7}
}
The hypothesis that adenosine acting on adenosine A1 receptors (A1R) regulates several renal functions and mediates tubuloglomerular feedback (TGF) was examined using A1R knockout mice. We anesthetized knockout, wild-type, and heterozygous mice and measured glomerular filtration rate, TGF response using the stop-flow pressure (P(sf)) technique, and plasma renin concentration. The A1R knockout mice had an increased blood pressure compared with wild-type and heterozygote mice. Glomerular… CONTINUE READING
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