Abolished InsP3R2 function inhibits sweat secretion in both humans and mice.

@article{Klar2014AbolishedIF,
  title={Abolished InsP3R2 function inhibits sweat secretion in both humans and mice.},
  author={Joakim Klar and Chihiro Hisatsune and Shahid M Baig and Muhammad Tariq and Anna C. V. Johansson and Mahmood Rasool and Naveed Altaf Malik and Adam Ameur and Kotomi Sugiura and Lars Feuk and Katsuhiko Mikoshiba and Niklas Dahl},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 11},
  pages={4773-80}
}
There are 3 major sweat-producing glands present in skin; eccrine, apocrine, and apoeccrine glands. Due to the high rate of secretion, eccrine sweating is a vital regulator of body temperature in response to thermal stress in humans; therefore, an inability to sweat (anhidrosis) results in heat intolerance that may cause impaired consciousness and death. Here, we have reported 5 members of a consanguineous family with generalized, isolated anhidrosis, but morphologically normal eccrine sweat… CONTINUE READING

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