AbobotulinumtoxinA: A Review in Pediatric Lower Limb Spasticity

@article{Syed2017AbobotulinumtoxinAAR,
  title={AbobotulinumtoxinA: A Review in Pediatric Lower Limb Spasticity},
  author={Yahiya Y. Syed},
  journal={Pediatric Drugs},
  year={2017},
  volume={19},
  pages={367-373}
}
AbobotulinumtoxinA (Dysport®) is currently the only botulinum toxin A formulation approved by the US FDA for the treatment of lower limb spasticity in pediatric patients aged ≥2 years. Intramuscular abobotulinumtoxinA was approved based on the results of a pivotal phase 3 trial in children with lower limb spasticity due to cerebral palsy. In this trial, a single treatment cycle with abobotulinumtoxinA 10–15 U/kg/leg injected into the gastrocnemius and soleus muscles significantly improved ankle… 
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Therapeutic possibilities of botulinum toxin in neurological disorders – treatment of limb spasticity in the course of brain damage
TLDR
The study provides current evidence regarding the safety and efficacy of botulinum toxin injection for spasticity of the upper and lower limbs in both adults and children.
Botulinum Toxin: Techniques Within Pediatric Physiatry
Intramuscular botulinum toxin injections are used for treatment of focal spasticity in children, particularly in those with a diagnosis of cerebral palsy. There are a variety of techniques used when…

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The efficacy and safety of abobotulinumtoxinA treatment in these previously treated patients were comparable with the overall trial population, indicating that doses of 10 and 15 U/kg/leg are suitable starting doses for children with spasticity regardless of the previous botulinum toxin preparation used.
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