Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism.

@article{Minno1993AbnormallyHT,
  title={Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism.},
  author={Giovanni di Minno and Giovanni Dav{\'i} and Maurizio Margaglione and Fedelia Cirillo and Elvira Grandone and Giovanni Ciabattoni and Isabella Catalano and Pietro Strisciuglio and Generoso Andria and Carlo Patrono},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 3},
  pages={1400-6}
}
Homocystinuria due to homozygous cystathionine beta-synthase deficiency is an inborn error of metabolism characterized by a high incidence of thrombosis and premature atherosclerosis. We evaluated TXA2 biosynthesis in vivo and several in vitro tests of platelet function in 11 homocystinuric patients and 12 healthy controls. In vitro, patients' platelet… CONTINUE READING