Abnormally high levels of brain N-acetylaspartate in children with sickle cell disease.

@article{Steen2005AbnormallyHL,
  title={Abnormally high levels of brain N-acetylaspartate in children with sickle cell disease.},
  author={R. Grant Steen and Robert J. Ogg},
  journal={AJNR. American journal of neuroradiology},
  year={2005},
  volume={26 3},
  pages={
          463-8
        }
}
BACKGROUND AND PURPOSE The most abundant metabolite visible by proton magnetic resonance spectroscopy (MRS) in human brain is N-acetylaspartate (NAA), which is often used as a marker of viable neurons. NAA is anecdotally reported to be elevated in children with sickle cell disease (SCD), even though patients can have brain injury or atrophy. We measured NAA levels rigorously in SCD patients to test the hypothesis that NAA is elevated in this patient population. METHODS We evaluated 26… CONTINUE READING

Similar Papers

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Effect of manganese chloride on the neurochemical profile of the rat hypothalamus.

  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2011
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

Proton MR spectroscopy of pediatric brain tumors.

  • Neuroimaging clinics of North America
  • 1998
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Proton MR spectroscopy of Wernicke encephalopathy.

  • AJNR. American journal of neuroradiology
  • 2002
VIEW 1 EXCERPT