Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria.

@article{Kamada2005AbnormallyDS,
  title={Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria.},
  author={Nobuhiko Kamada and Tadakazu Hisamatsu and Susumu Okamoto and Toshiro Sato and Katsuyoshi Matsuoka and Kumiko Arai and Takaaki Nakai and Akira Hasegawa and Nagamu Inoue and Noriaki Watanabe and Kiyoko S. Akagawa and Toshifumi Hibi},
  journal={Journal of immunology},
  year={2005},
  volume={175 10},
  pages={6900-8}
}
Disorders in enteric bacteria recognition by intestinal macrophages (Mphi) are strongly correlated with the pathogenesis of chronic colitis; however the precise mechanisms remain unclear. The aim of the current study was to elucidate the roles of Mphi in intestinal inflammation by using an IL-10-deficient (IL-10-/-) mouse colitis model. GM-CSF-induced bone marrow-derived Mphi (GM-Mphi) and M-CSF-induced bone marrow-derived Mphi (M-Mphi) were generated from bone marrow CD11b+ cells. M-Mphi from… CONTINUE READING

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