Abnormality of circulating CD4<ce:sup loc=post>+</ce:sup>CD25<ce:sup loc=post>+</ce:sup> regulatory T cell in patients with Guillain–Barré syndrome

@article{Chi2007AbnormalityOC,
  title={Abnormality of circulating CD4<ce:sup loc=post>+</ce:sup>CD25<ce:sup loc=post>+</ce:sup> regulatory T cell in patients with Guillain–Barr{\'e} syndrome},
  author={Li-jun Chi and Hua-bing Wang and Ying Zhang and Wei-Zhi Wang},
  journal={Journal of Neuroimmunology},
  year={2007},
  volume={192},
  pages={206-214}
}
CD4CD25 T regulatory cells (Tregs), a subset of CD4 T cells expressing high levels of CD25 and the transcription factor Foxp3, are critical in maintaining immunologic homeostasis and preventing autoimmunity by suppressing self-reactive T cells. Guillain–Barré syndrome (GBS) is thought to be a self-limiting, autoimmune disease of the peripheral nervous system. We hypothesized that altered frequency and/or function of Tregs play a role in the breakdown of immunologic self-tolerance in GBS… CONTINUE READING

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