Abnormality in cultured oligodendrocytes and Schwann cells isolated from the twitcher mouse.

@article{Ida1990AbnormalityIC,
  title={Abnormality in cultured oligodendrocytes and Schwann cells isolated from the twitcher mouse.},
  author={Hirohisa Ida and F Kawame and Seung Up Kim and Y Eto},
  journal={Molecular and chemical neuropathology},
  year={1990},
  volume={13 3},
  pages={
          195-204
        }
}
Oligodendrocytes and Schwann cells were isolated from the brain and dorsal root ganglia of the twitcher mouse, a murine model of Krabbe's disease (globoid cell leukodystrophy), and grown in tissue culture. Oligodendrocytes were cultured for up to 22 d in vitro and were immunostained with a galactocerebroside antibody, a specific marker for oligodendrocytes. The control oligodendrocytes developed well-branched processes and membrane sheets, whereas the twitcher oligodendrocyte had wirelike… CONTINUE READING

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