Abnormalities of the FHIT gene in human oral carcinogenesis

  title={Abnormalities of the FHIT gene in human oral carcinogenesis},
  author={Keiji Tanimoto and Shin-ichi Hayashi and Eiju Tsuchiya and Yoshio Tokuchi and Yukio Kobayashi and Koji Yoshiga and Toyo Okui and Masashi Kobayashi and Toru Ichikawa},
  journal={British Journal of Cancer},
  pages={838 - 843}
The abnormalities of the fragile histidine triad (FHIT) gene in tissue samples of oral squamous cell carcinomas (SCCs) along with several leukoplakias and an erythroplakia were examined to determine whether the FHIT gene is actually a frequent target in vivo for alteration during oral carcinogenesis. Abnormal transcripts of the FHIT gene were found in eight… CONTINUE READING