Abnormalities of the ARF-p53 pathway in oral squamous cell carcinoma

  title={Abnormalities of the ARF-p53 pathway in oral squamous cell carcinoma},
  author={G Bradley and Jonathan C. Irish and Christina Macmillan and Kent Mancer and Ian Witterick and Warren Hartwick and Patrick Gullane and Suzanne Kamel-Reid and Sam Benchimol},
Oral squamous cell carcinoma (OSCC) is associated with heavy smoking and drinking, but the molecular pathway of tumorigenesis is not understood. Inactivation of the p53 tumor suppressor gene is likely to play an important role since p53 mutation is frequently found. The p14ARF tumor suppressor gene is functionally linked to p53, because it is activated by oncogenes and causes p53-dependent growth arrest and apoptosis. The relationship between p14ARF and p53 inactivation has not been described… CONTINUE READING


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