Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome.

@article{Moretti2005AbnormalitiesOS,
  title={Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome.},
  author={Paolo Moretti and Jan Adriaan Bouwknecht and Ryan M. Teague and Richard E Paylor and Huda Y. Zoghbi},
  journal={Human molecular genetics},
  year={2005},
  volume={14 2},
  pages={205-20}
}
Rett syndrome (RTT) is an autistic spectrum disorder with a known genetic basis. RTT is caused by loss of function mutations in the X-linked gene MECP2 and is characterized by loss of acquired motor, social and language skills in females beginning at 6-18 months of age. MECP2 mutations also cause non-syndromic mental retardation in males and females, and abnormalities of MeCP2 expression in the brain have been found in autistic spectrum disorders. We studied home-cage behavior and social… CONTINUE READING
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