Abnormalities of smooth pursuit and saccadic control in schizophrenia and affective disorders

  title={Abnormalities of smooth pursuit and saccadic control in schizophrenia and affective disorders},
  author={Larry A. Abel and Smadar Levin and Philip S. Holzman},
  journal={Vision Research},

Timing and amplitude of saccades during predictive saccadic tracking in schizophrenia.

The reaction time results are unlikely to be an effect of treatment with antipsychotic medication and are inconsistent with the hypothesis that schizophrenia patients have frontal eye field pathology.

Saccadic eye movements in schizophrenic patients

Smooth pursuit performance in patients with affective disorders or schizophrenia and normal controls: analysis with specific oculomotor measures, RMS error and qualitative ratings

Data indicate two smooth pursuit performance deficits in schizophrenia: patients spend less time engaged in scoreable smooth pursuit and have low gain (accompanied by increased compensatory saccades) when the smooth pursuit is engaged.

Mixture analysis of smooth pursuit eye movements in schizophrenia.

Findings indicating that the eye movement data of schizophrenic patients is best represented by the mixture of two groups, one of which has distinctly poor performance are replicated and extended.

Comparison of the smooth eye tracking disorder of schizophrenics with that of nonhuman primates with specific brain lesions.

The ETD following lesions of the frontal lobe is unique in that it closely resembles the ETD of schizophrenics and lends further support for frontal lobe theories of schizophrenia.

Target anticipation and impairment of smooth pursuit eye movements in schizophrenia

Abstract A reduced gain of smooth pursuit eye velocity has frequently been reported in schizophrenic patients. With respect to predictable stimuli, this could be due to a deficit in predicting the

Eye tracking dysfunction in schizophrenia: characterization and pathophysiology.

The evidence suggests that ETD involves higher-order structures, including the frontal eye fields, which adjust the gain of the pursuit response to visual and anticipated target movement, as well as early parts ofThe pursuit pathway, including motion areas (the middle temporal area and the adjacent medial superior temporal area).

Smooth pursuit and antisaccade eye movements as endophenotypes in schizophrenia spectrum research.

The results generally confirmed the validity of the SPEM and antisaccade deficits as schizophrenia spectrum endophenotypes: Oculomotor performance was mostly stable both within and between assessments.



Smooth pursuit eye movements in schizophrenics—What constitutes quantitative assessment?

Pharmacologic evidence for specificity of pursuit dysfunction to schizophrenia. Lithium carbonate associated with abnormal pursuit.

The findings support the specificity of abnormal pursuit as a biological trait associated with schizophrenia, but not with the major affective disorders, as well as the mechanisms by which lithium carbonate impairs pursuit.

Eye-tracking dysfunctions in schizophrenic patients and their relatives.

The findings suggest proprioceptive and interoceptive involvement in schizophrenic pathology and the eye-tracking dysfunction may represent a genetic marker that can prove highly useful for studying the transmission of a vulnerability to schizophrenia.

Eye movements in schizophrenia.

The frequency and severity of eye movement abnormalities in schizophrenic patients are lower than those indicated by previous studies that used different techniques of analysis.

Pursuit eye movement dysfunctions in schizophrenia. Family evidence for specificity.

The data suggest that, in the absence of other CNS disease, these eye tracking dysfunctions represent familial markers of vulnerability to schizophrenia.

Oculomotor abnormalities and their clinical correlates in schizophrenia.

A battery of oculomotor measures to be administered to a large number of clinically well described schizophrenic patients and normal controls indicate that this technique of studying multiple paradigms for oculumotor control in schizophrenia may prove to be fruitful.

Quantitative analysis of eye movements in schizophrenia

The authors' results could demonstrate both a dysfunction of smooth pursuit which was related to a low smooth pursuit gain and an increase of small catch-up saccades, respectively, and dysmetric visually-induced reflexive sac-cades.

Smooth pursuit eye movements, attention, and schizophrenia.

The data indicate that nonvoluntary attending is specifically disordered in schizophrenics and their relatives, and implicate a neurophysiological substrate that can be described as a failure of inhibitory, synchronizing integrating systems which may be located in the brain stem.