Abnormalities of sarcoplasmic reticulum Ca2+ mobilization in aortic smooth muscle cells from streptozotocin-induced diabetic rats.

@article{Ma2008AbnormalitiesOS,
  title={Abnormalities of sarcoplasmic reticulum Ca2+ mobilization in aortic smooth muscle cells from streptozotocin-induced diabetic rats.},
  author={Li Ma and Banghao Zhu and Xiangping Chen and Jie Liu and Yongyuan Guan and Jun Ren},
  journal={Clinical and experimental pharmacology & physiology},
  year={2008},
  volume={35 5-6},
  pages={568-73}
}
1. Previously, we found that contractions in response to receptor-dependent (i.e. a(1)-adrenoceptor agonist phenylephrine) and -independent (i.e. cyclopiazonic acid) stimuli are decreased in rat aorta during late diabetes. The aim of the present study was to further investigate the changes of intracellular Ca(2+) homeostasis in diabetic aortic smooth muscle cells. Functional changes of inositol 1,4,5-trisphosphate (IP(3))- and ryanodine-sensitive Ca(2+) stores of the sarcoplasmic reticulum (SR… CONTINUE READING
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