Abnormalities of one-carbon metabolism in psychiatric disorders: study of methionine adenosyltransferase kinetics and lipid composition of erythrocyte membranes.

@article{Smythies1986AbnormalitiesOO,
  title={Abnormalities of one-carbon metabolism in psychiatric disorders: study of methionine adenosyltransferase kinetics and lipid composition of erythrocyte membranes.},
  author={John R. Smythies and Renato D Alarc{\'o}n and D A Morere and Juan Alberto Monti and Marjorie Steele and Lelland C Tolbert and W G Walter-Ryan},
  journal={Biological psychiatry},
  year={1986},
  volume={21 14},
  pages={1391-8}
}
Two independent lines of inquiry have implicated some disturbance of one-carbon cycle metabolism in affective disorders. Folic acid deficiency commonly leads to depression, and S-adenosylmethionine has been reported to have antidepressant properties. Methionine adenosyltransferase has been reported to be underactive in depression and schizophrenia and overactive in mania. This study reports the effects on erythrocyte methionine adenosyltransferase (MAT) kinetics (Vmax) of a 2-week treatment in… CONTINUE READING