Abnormalities of mitochondrial enzymes in Alzheimer disease

  title={Abnormalities of mitochondrial enzymes in Alzheimer disease},
  author={Gary E Gibson and K. -F. R. Sheu and John P. Blass},
  journal={Journal of Neural Transmission},
Abundant evidence, including critical information gathered by Prof. Siegfried Hoyer and his colleagues, indicates that abnormalities of cerebral metabolism are common in neurodegenerative diseases, including Alzheimer's Disease (AD). Alterations in mitochondrial enzymes likely underlie these deficits. Replicable reductions in AD brain occur in the pyruvate dehydrogenase complex (the link of glycolysis to the Kreb's cycle), the α-ketoglutarate dehydrogenase complex (KGDHC; the link of Kreb's… CONTINUE READING
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