Abnormalities of lymphokine gene expression in patients with common variable immunodeficiency.

@article{Sneller1990AbnormalitiesOL,
  title={Abnormalities of lymphokine gene expression in patients with common variable immunodeficiency.},
  author={Michael C Sneller and Warren Strober},
  journal={Journal of immunology},
  year={1990},
  volume={144 10},
  pages={3762-9}
}
Common variable immunodeficiency (CVI) is a syndrome characterized by hypogammaglobulinemia, recurrent bacterial infections, and increased occurrence of both autoimmune disease and malignancy. In our study we examine the expression of lymphokine genes in mitogen-activated T cells from four patients with CVI. T cells from patients with CVI did not differ significantly from normals in total T cell number, CD4/CD8 ratio, CD45R expression, or proliferation in response to PHA. However, T cells from… CONTINUE READING