Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects

@article{Greene1998AbnormalitiesOF,
  title={Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects},
  author={Nicholas D.E Greene and Dianne Gerrelli and Henny W. M. van Straaten and Andrew J Copp},
  journal={Mechanisms of Development},
  year={1998},
  volume={73},
  pages={59-72}
}
Mouse embryos homozygous for the loop-tail (Lp) mutation fail to initiate neural tube closure at E8.5, leading to a severe malformation in which the neural tube remains open from midbrain to tail. During initiation of closure, the normal mouse neural plate bends sharply in the midline, at the site of the future floor plate. In contrast, Lp/Lp embryos exhibit a broad region of flat neural plate in the midline, displacing the sites of neuroepithelial bending to more lateral positions. Sonic… CONTINUE READING