Abnormalities of developmental cell death in Dad1-deficient mice.

  title={Abnormalities of developmental cell death in Dad1-deficient mice.},
  author={Kiyomasa Nishii and Takahiro Tsuzuki and Madoka Kumai and Naoki Takeda and Hisashi Koga and Shinichi Aizawa and Takeharu Nishimoto and Yosaburo Shibata},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={4 4},
BACKGROUND Dad1, the defender against apoptotic cell death, comprises the oligosaccharyltransferase complex and is well conserved among eukaryotes. In hamster BHK21-derived tsBN7 cells, loss of Dad1 causes apoptosis which cannot be prevented by Bcl-2. RESULTS To determine the role of Dad1 function in vivo, we prepared by gene targeting, mice harbouring a disrupted Dad1 gene. Homozygous mutants died shortly after they were implanted with the characteristic features of apoptosis. In an in vitro… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…