Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors.

@article{Baluk2003AbnormalitiesOB,
  title={Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors.},
  author={Peter Baluk and Shunichi Morikawa and Amy Haskell and Michael Mancuso and D M Mcdonald},
  journal={The American journal of pathology},
  year={2003},
  volume={163 5},
  pages={1801-15}
}
Often described as incomplete or absent, the basement membrane of blood vessels in tumors has attracted renewed attention as a source of angiogenic and anti-angiogenic molecules, site of growth factor binding, participant in angiogenesis, and potential target in cancer therapy. This study evaluated the composition, extent, and structural integrity of the basement membrane on blood vessels in three mouse tumor models: spontaneous RIP-Tag2 pancreatic islet tumors, MCa-IV mammary carcinomas, and… CONTINUE READING